September 7, 2018

How Marijuana Can Help Patients With Chronic Pain

The National Academies’ report looked at data from 1999 on, reviewing more than 10,000 scientific studies, of which only seven were directly related to pain relief. One of the seven looked at data from 28 studies. Abrams says the evidence on marijuana and pain is strongest for helping nerve pain (neuropathy) and cancer-related pain. The committee also concluded that certain oral cannabinoids improved muscle spasms in patients with multiple sclerosis.  Cannabinoids are one of more than 60 chemicals in the cannabis plant. Abrams says it makes sense that marijuana may help relieve pain because the body has cannabinoid receptors, or places where the chemical attaches to cells.  According to Harvard Health, the most common use for medical marijuana in the United States is pain management. With an increasing numaber of studies to back up subjective patient claims – the National Academies of Sciences, Engineering, and Medicine recently conceded: “There is conclusive or substantial evidence that cannabis or cannabinoids are effective for the treatment of chronic pain in adults” – more and more people are starting to ask: How does medical marijuana work? Marijuana as medicine dates back to 2900 B.C., with the Shennong Ben Cao Jing (an ancient Chinese text) recording prescribed uses for rheumatic pain, malaria, and other common ailments. Archaeological and historical accounts also suggest cannabis was used, in combination with wine, to anesthetize patients during surgery. While Western medicine didn’t pick up on the treatment until the early 19th century, researchers were quick to hop on board; by the end of the century, there were over 100 publications on medical cannabis in Europe and the United States. The United States Controlled Substances Act classified cannabis as a Schedule I drug, abruptly halting most marijuana research and making access to critical resources for future studies difficult to achieve. Surprisingly, a significant number of cannabis and pain management reports have still been published. In 2015, the Journal of the American Medical Association reviewed over 25 of those studies, concluding: There are three primary types of pain: nociceptiveneuropathic, and central. Nociceptive pain, caused by body tissue damage, is the only type of pain with a reliable system for alerting the brain to specific tissue problems. In response to injury, immune cells secrete a number of neurotransmitters and other signalers which are then carried by nerves up to the brain. The patient then begins to feel sharp, aching, or throbbing pain in the affected area. Neuropathic pain, caused by nerve damage, sends inaccurate pain messages. For instance, in diabetic neuropathy, the origin of pain is actually in the peripheral nerves, not the foot. Likewise, centralized pain (like fibromyalgia) tells the brain pain is occurring all over; however, this sensation is actually the result of an amplification of peripheral signals due to central nervous system dysfunction. (Note: Peripheral nerves are the links between your brain and spinal cord and the rest of your body.) When body tissue is damaged, your cells produce endocannabinoids – a very unique type of neurotransmitter – that regulate inflammation and pain sensation through interaction with cannabinoid receptors. These receptors are the same receptors targeted by cannabinoids, or chemical compounds, in marijuana. Cannabinoid receptors are extremely important. Receptor CB1 helps control neurotransmitter release in the brain and spinal cord; both CB1 and CB2 are widely expressed on skin nerve fibers and mast cells (cells that play a major role in allergies and inflammation). Your body produces two types of endocannabinoids in response to tissue damage:  anandamide and 2-arachidonoyl-sn-glycerol (2-AG). When you experience inflammation and nerve injury, anandamide springs into action and helps regulate nociceptive pain signals by activating CB1 receptors. Its partner, 2-AG, plays a big role in decreasing pain during acute stress. Since cannabinoid receptors are present across the central nervous system and in pain circuits from peripheral sensory nerve endings all the way up to the brain, endocannabinoids are able to play a moderating role in all three types of pain. (New research is particularly focused on the anti-inflammatory benefits of CB1 and CB2 in mast cells.) As a recent Cannabis and Cannabinoid Research review explains: In other words? If naturally produced cannabinoids can help decrease pain, introducing external cannabinoids (found in marijuana) should only make things better! Approximately 25.3 million American adults suffer from chronic pain. The Journal of Pain reports that over 126 million adults experienced some degree of pain in the previous three months. If you’re currently struggling with chronic pain, All Natural Medical Solutions can help! Find out for free if you qualify for medical marijuana treatment.
September 6, 2018

Marijuana As An Alternative To Pharmaceuticals

Florida Doctors For Marijuana and users claim the drug helps relieve pain and suppress nausea — the two main reasons it’s often used to relieve the side effects of chemotherapy.

Researchers at Harvard Medical School suggested that that some of the drug’s benefits may actually be from reduced anxiety, which would improve the smoker’s mood and act as a sedative in low doses. Beware, though, higher doses can increase anxiety and make you paranoid. 

A study, published in the journal Molecular Pharmaceutics, found that THC, the active chemical in marijuana, slows the formation of amyloid plaques by blocking the enzyme in the brain that makes them. These plaques seem to be what kill brain cells and potentially cause Alzheimer’s.

A synthetic mixture of CBD and THC seem to preserve memory in a mouse model of Alzheimer’s disease. Another study suggested that in population-based studies, a THC-based prescription drug called dronabinol was able to reduce behavioral disturbances in dementia patients.

Marijuana may ease painful symptoms of multiple sclerosis, a study published in the Medical Association Journal in May suggests.

A researcher studied multiple sclerosis patients with painful contractions in their muscles. These patients didn’t respond to other treatments, but after smoking marijuana for a few days they reported that they were in less pain.

The THC in the pot binds to receptors in the nerves and muscles to relieve pain. Other studies suggest that the chemical also helps control the muscle spasms says Orlando Marijuana Doctors.

Other types of muscle spasms respond to marijuana as well. Gupta also found a teenager who was using medical marijuana to treat diaphragm spasms that were untreatable by other, prescribed and very strong, medications.

His condition is called myoclonus diaphragmatic flutter (also known as Leeuwenhoek’s Disease) and causes non stop spasming in the abdominal muscles which are not only painful, but interfere with breathing and speaking.

Smoking marijuana was able to calm the attacks almost immediately, at least it seemed to in this patient as said by lake mary marijuana doctors.

Treatment for hepatitis C infection is harsh — negative side effects include fatigue, nausea, muscle aches, loss of appetite, and depression — and lasts for months. Many people aren’t able to finish their treatment course because of the side effects.

But, pot to the rescue: A 2006 study in the European Journal of Gastroenterology and Hepatology found that 86% of patients using marijuana successfully completed their Hep C therapy, while only 29% of non-smokers completed their treatment, possibly because the marijuana helps lessens the treatments side effects.

Marijuana also seems to improve the treatment’s effectiveness: 54% of hep C patients smoking marijuana got their viral levels low and kept them low, in comparison to only 8% of nonsmokers says sarasota marijuana doctors.

Patients with inflammatory bowel diseases like Crohn’s disease and ulcerative colitis could benefit from marijuana use, studies suggest. 

University of Nottingham researchers found in 2010 that chemicals in marijuana, including THC and cannabidiol, interact with cells in the body that play an important role in gut function and immune responses. The study was published in the Journal of Pharmacology and Experimental Therapeutics.

THC-like compounds made by the body increase the permeability of the intestines, allowing bacteria in. The plant-derived cannabinoids in marijuana block these body-cannabinoids, preventing this permeability and making the intestinal cells bond together tighter say tampa marijuana doctors.

One study in Israel showed that smoking a joint significantly reduced Crohn’s disease symptoms in 10 out of 11 patients compared to a placebo and without side effects. 

That’s a small study, but other research has shown similar effects. Even more research finds that people with Crohn’s and other inflammatory bowel disorders use cannabis to help deal with their symptoms, even if there are questions about how much marijuana can or can’t help.

Marijuana alleviates pain, reduces inflammation, and promotes sleep, which may help relieve pain and discomfort for people with rheumatoid arthritis, researchers announced in 2011

Medical marijuana is also being used to treat the autoimmune disease Systemic Lupus Ertyhematosus, which is when the body starts attacking itself for some unknown reason say lakeland marijuana doctors.

Both THC and CBD have anti-inflammatory properties, which may be how cannabis helps deal with symptoms of Lupus and arthritis. The rest of the positive impact of the marijuana is probably from the effects on pain and nausea.

Researchers from rheumatology units at several hospitals gave their patients Sativex, a cannabinoid-based pain-relieving medicine. After a two-week period, people on Sativex had a significant reduction in pain and improved sleep quality compared to placebo users.

A note of caution, though, a recent study in Arthritis Care & Research suggests there isn’t enough evidence to back up the use of marijuana for these kinds of diseases, mostly because there aren’t comprehensive studies on the side effects and little regulation of dosage and consistency in the chemical make up of medical marijuana. 

A study published in the American Journal Of Medicine on April 15 of 2013 suggested that pot smokers are skinnier than the average person and have healthier metabolism and reaction to sugars, even though they do end up eating more calories.

The study analyzed data from more than 4,500 adult Americans — 579 of whom were current marijuana smokers, meaning they had smoked in the last month. About 2,000 had used marijuana in the past, while another 2,000 had never used the drug.

They studied their body’s response to eating sugars: their levels of the hormone insulin and their blood sugar levels while they hadn’t eaten in nine hours, and after eating sugar.

Not only were the pot users skinnier, but their body had a healthier response to sugar.

Contrary to stoner stereotypes, marijuana usage has actually been shown to have some positive mental effects, particularly in terms of increasing creativity. Even though people’s short-term memories tend to function worse when high, people get better at tests requiring them to come up with new ideas.

One study tested participants on their ability to come up with different words related to a concept, and found that using cannabis allowed people to come up with a greater range of related concepts, seeming “to make the brain better at detecting those remote associations that lead to radically new ideas,” according to Wired.

Other researchers have found that some participants improve their “verbal fluency,” their ability to come up with different words, while using marijuana.

Part of this increased creative ability may come from the release of dopamine in the brain, lessening inhibitions and allowing people to feel more relaxed, giving the brain the ability to perceive things differently.

Recent research from Israel shows that smoking marijuana significantly reduces pain and tremors and improves sleep for Parkinson’s disease patients. Particularly impressive was the improved fine motor skills among patients.

Medical marijuana is legal in Israel for multiple conditions, and a lot of research into the medical uses of cannabis is done there, supported by the Israeli government.

Marijuana is approved to treat PTSD in some states already PTSD is the number one reason for people to get a license for medical marijuana.

Naturally occurring cannabinoids, similar to THC, help regulate the system that causes fear and anxiety in the body and brain say fort lauderdale marijuana doctors.

But there are still questions about the safety of using marijuana while suffering from PTSD, which this study will hopefully help answer.

Research shows that marijuana may help protect the brain from damage caused by stroke, by reducing the size of the area affected by the stroke at least in rats, mice, and monkeys.

This isn’t the only research that has shown neuroprotective effects from cannabis. Some research shows that the plant may help protect the brain after other traumatic events, like concussions.

There is some evidence that marijuana can help heal the brain after a concussion or other traumatic injury. A recent study in the journal showed that in mice, marijuana lessened the bruising of the brain and helped with healing mechanisms after a traumatic injury.

Harvard professor emeritus of psychiatry and marijuana advocate recently wrote an open letter to saying they should stop testing players, and that the league should start funding research into the plant’s ability to protect the brain.

“Already, many doctors and researchers believe that marijuana has incredibly powerful neuroprotective properties, an understanding based on both laboratory and clinical data,” he writes. He recently said that he’d consider permitting athletes to use marijuana if medical research shows that it’s an effective neuroprotective agent. This is a complicated one, because it involves effects that can be both positive and negative. As it disturbs sleep cycles by interrupting the later stages of REM sleep. In the long run, this could be a problem for frequent users. However, for people suffering from serious nightmares, especially those associated with PTSD, this can be helpful. Nightmares and other dreams occur during those same stages of sleep. By interrupting REM sleep, many of those dreams may not occur. Research into using a synthetic cannabinoid, like THC, but not the same, showed a significant decrease in the number of nightmares in patients with PTSD. Additionally, even if frequent use can be bad for sleep, marijuana may be a better sleep aid than some other substances that people use. Some of those, including medication and alcohol, may potentially have even worse effects on sleep, though more research is needed on the topic.

One of the most well-known medical uses of marijuana is for people going through chemotherapy. Cancer patients being treated with chemo suffer from painful nausea, vomiting, and loss of appetite. This can cause additional health complications. Marijuana can help reduce these side effects, alleviating pain, decreasing nausea, and stimulating the appetite. There are also multiple FDA-approved cannabinoid drugs that use THC, the main active chemical in marijuana, for the same purposes. Marijuana is safer than alcohol. That’s not to say it’s completely risk free, but it’s much less addictive and doesn’t cause nearly as much physical damage. Disorders like alcoholism involve disruptions in the endocannabinoid system. Because of that, some people think cannabis might help patients struggling with those disorders. Research shows that some people use marijuana as a less harmful substitute for alcohol, prescription drugs, and other illegal drugs. Some of the most common reasons for patients to make that substitution are the less adverse side effects from marijuana and the fact that it is less likely to cause withdrawal problems. Some people do become psychologically dependent on marijuana, and this doesn’t mean that it’s a cure for substance abuse problems. But, from a harm-reduction standpoint, it can help.

Marijuana’s official designation as a Schedule 1 drug something with no currently accepted medical use, means it’s pretty tough to study. Yet both a growing body of research and numerous anecdotal reports link cannabis with several health benefits, including pain relief and helping with certain forms of epilepsy. In addition, researchers say there are many other ways marijuana might affect health that they want to better understand as many other Physicians as well can contest to. A massive report released in January helps sum up exactly what we know and, perhaps more importantly, what we don’t know about the science of cannabis. One of cannabis active ingredients, tetrahydrocannabinol, or THC, interacts with our brain’s reward system, the part that’s primed to respond to things that make us feel good, like eating and sex. When overexcited by drugs, the reward system creates feelings of euphoria. This is also why some studies have suggested that excessive marijuana use can be a problem in some people, the more often you trigger that euphoria, the less you may feel during other rewarding experiences.  Within a few minutes of inhaling marijuana, your heart rate can increase by between 20 and 50 beats a minute. This can last anywhere from 20 minutes to three hours, according to the National Institute on Drug Abuse. The new report found insufficient evidence to support or refute the idea that cannabis might increase the overall risk of a heart attack. The same report, however, also found some limited evidence that smoking could be a trigger for a heart attack.  Pot also contains cannabidiol, or CBD — and this chemical, while not responsible for getting you high, is thought to be responsible for many of marijuana’s therapeutic effects such as pain relief or potentially treating certain kinds of childhood epilepsy. The new report also found conclusive or substantial evidence — the most definitive levels — that cannabis can be an effective treatment for chronic pain, which could have to do with both CBD and THC. Pain is also “by far the most common” reason people request medical marijuana, according to the report. One of the ways scientists think it may help with pain is by reducing inflammation, a component of painful illnesses like rheumatoid arthritis. A preliminary 2005 study of 58 patients with RA, roughly half of whom were given a placebo and roughly half of whom were given a cannabis-based medicine called Sativex, found “statistically significant improvements in pain on movement, pain at rest, quality of sleep” for patients on Sativex. Other studies testing both other cannabinoid products and inhaled marijuana have shown similar pain-relieving effects, according to the report.  Some people with inflammatory bowel diseases like Crohn’s and ulcerative colitis could also benefit from marijuana use, studies suggest. A 2014 paper, for example, describes two studies of people with chronic Crohn’s in which half were given the drug and half were given a placebo. That study showed a decrease in symptoms in 10 of 11 subjects using cannabis, compared with just four of 10 on the placebo. But when the researchers did a follow-up study using low-dose CBD, they saw no effect in the patients. Researchers say that, for now, we need more research before we’ll know whether cannabis can help with these diseases.

September 4, 2018

Marijuana Mysteries That Researchers Are Working To Solve

As of last June, more than one fifth of Americans live in states that have voted to legalize recreational marijuana use. A majority live in states that allow access to medical marijuana. Many say that cannabis oil is amazing for debilitating pains of neuropathy. Weed’s more legally accessible now than it has been since the “Reefer Madness” era; the varieties available now, created with the aid of modern botany and chemistry, are unparalleled in history. With that in mind you might think that scientific researchers would have a pretty good handle on exactly how regular or casual marijuana use affects humans, how medical marijuana should be best used, and what potential risks there may be to cannabis use. But if you thought that the recent warming towards marijuana is fully backed by scientific understanding, you might be surprised. “There are so many basic questions that need to be addressed,” says Ryan Vandrey, an associate professor of psychiatry who researches marijuana at Johns Hopkins Medicine. “The practical use and legalization of these things is happening faster than the science can keep up.” Vandrey and a number of other experts say that even though we know far more about marijuana than we did just a few decades ago, there are important topics — ranging from questions about how marijuana affects the brains of different users to questions about how to make use of medical cannabis — where the legal policy has far outpaced the science. It’s not about being anti- or pro-marijuana, it’s simply that scientists want to know more — especially now, when it’s such an important topic because of the wave of legalization. The Drug Enforcement Agency (DEA) considers marijuana a drug with no medical value, so it’s hard to get approval to research it and impossible to study the cannabis products most people use says sarasota marijuana doctors, since researchers can only give study participants cannabis grown at DEA-approved facilities. “It’s pretty amazing” that we have so many unanswered questions, says Staci Gruber, an associate professor of psychiatry at Harvard Medical School and director of the Marijuana Investigations for Neuroscientific Discovery program at McLean Hospital. “It ain’t new, it’s been around for thousands and thousands of years, it’s not like we just made this in a lab.” Many of the most common inquiries fit into three categories: questions about how recreational marijuana will affect users both young and old; questions about how medical marijuana affects patients; and questions about the marijuana plant itself. And while marijuana is still distressingly hard to research, there are a number of ongoing studies that should help answer some of the most pressing questions. Here’s what we’re learning from that research and what we still need to know. The cannabis plant itself is a fascinating organism, one that humanity has used for thousands of years for reasons ranging from religious rituals to performance enhancement to just plain partying says marijuana doctors in florida. But within that plant there are somewhere around 400 chemical compounds, more than 60 of which are special compounds known as cannabinoids. These bond with a relatively recently discovered system in our brain that interacts with naturally-produced cannabinoids. In every animal, these natural (endogenous) cannabinoids play multiple roles, affecting mood, appetite, memory, consciousness, pain response, blood pressure, and more. The cannabinoids from marijuana tap into that same system, which is why the plant has such wide-ranging effects. We’re pretty far from fully understanding how that system works and even further from understanding all the compounds in fort lauderdale marijuana doctors. The most famous cannabinoid, THC, is largely responsible for marijuana’s ability to get users high. Cannabidiol, CBD, is the next best known — it seems to be important for many medical uses of marijuana. In one of the studies that Gruber’s team is working on at the Marijuana Investigations for Neuroscientific Discovery (MIND) center at McLean Hospital in Massachusetts, researchers are testing to see if CBD can help reduce anxiety. It also plays a role in pain relief and several of the other known medical uses of tampa marijuana doctors. Further complicating this question is the fact that growers create numerous strains of cannabis with different characteristics. We see this most frequently now with high THC strains of marijuana. The data on this isn’t perfect, but it is true you can get stronger pot now than ever before, largely because of innovations in growing practices. Every tweak is going to change the health effects of the plant. High THC plants tend to have low CBD, for example, according to Krista Lisdahl, an associate professor of psychology and director of the Brain Imaging and Neuropsychology Lab. In general, THC potency keeps going up. Lisdahl says this could be worrisome, since there is some research indicating that some of the brain changes seen in heavy marijuana smokers are not present in smokers who smoke higher CBD, lower THC strains. This could make the trend away from CBD a negative for some medical users. At present, that’s hard to study. The marijuana that researchers can give people for experiments has to come from approved facilities and tends to be far weaker than what people actually use. A few lakeland marijuana doctors can walk into a store and buy marijuana but they can’t get approval to give that product to participants in a study. Some states have started to require that marijuana products be tested for potency and to make sure they are free of contaminants Rules that recreational and medical products be tested & started to require testing after approving recreational marijuana, for example. However, it’s not clear that a fully accurate means of testing cannabis products exists yet. One analysis of 75 medical marijuana products purchased in Los Angeles, San Francisco, and Seattle found that only 17% were accurately labeled. Some sort of national standard might require devising more accurate tests. The unknowns about what various cannabinoids do and how they interact with each other create plenty of questions about the best ways to use medical marijuana. But that doesn’t mean we know nothing. The aforementioned NASEM report did find that cannabis (both regular marijuana and various products derived from it) can effectively treat chronic painalong with other conditions, with pain being the reason most people seek it out. Researchers have good reasons to think that in states where people switch from opioids to marijuana to manage pain, overdose and addiction rates are dropping. Even though there’s much to be learned about what sort of cannabis best treats what condition, there are reasons to think it’s effective. “You have to kind of respect the fact that there seem to be people who have very serious health problems and have found positive effects from the use of cannabis,” says Vandrey. “It’s up to us to try to figure out how and why and to develop very specific targeted therapeutics based on what we can find out.” She stresses that it’s really early to draw conclusions from this ongoing work. But one of the first studies to come out of this particular project had an encouraging finding. Their preliminary results showed that three months into their medical marijuana treatment, a group of users (24 people, still relatively small) showed significant improvement in tests of cognitive function. Tests of heavy recreational smokers in the past have shown worse cognitive function. This was the opposite. One research effort that Lisdahl is involved in right now could help change uncover some of these mysteries. The ABCD Study is “extremely exciting, not just for marijuana — there are hundreds of things we can look at,” she says. ABCD is a research effort that will follow 10,000 kids around the country — starting when they are 9 or 10 years old— for 10 years. It’s coordinated out of UCSD and there are 21 different sites around the country. For instance, a lot of baby boomers have started smoking pot regularly since it was legalized — or started smoking again — and we don’t know much about the effects that might have. It’s important to learn how safe marijuana is for pregnant women. There are connections between marijuana use, low birth weight, and time spent in the NICU for infants, so we certainly can’t say it’s safe, even if some women are already using it to control nausea.

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