Cannabis commonly known as marijuana is being used widely for recreational or medicinal purposes. Have you ever pondered the edibles that you are taking inside your body, what they are capable of doing? How do your organs respond to them? And most importantly what power they hold to cast the effect on your body?   Let’s go down a brief introduction to get known about the chemistry between your body and marijuana to understand what happens in the liver when you ingest the cannabis.  

What comes off when you ingest marijuana?

Everything that we take orally has to go through a first-pass effect. It means the things that we ingest have to go down the digestive tract and are entered and metabolized in the liver. And then finally, they become part of the bloodstream.   When marijuana edibles are ingested they follow the first-pass effect and enter the liver. The liver is the powerhouse of the body. It metabolizes cannabis, and cannabinoids are produced as a result of hepatic metabolism.   These cannabinoids upon consumption produce a psychoactive effect on the body and mind. More specifically, tetrahydrocannabinol (THC) is a cannabinoid that causes the euphoric and intoxicating effect, while cannabidiol (CBD) is responsible for therapeutic effects. The more the dose of cannabis, the more powerful, euphoric, and the long-lasting results of cannabis appear. Ingested cannabis effects are more intense and of longer duration than inhaled cannabis. After ingestion, cannabis takes time to onset its effect as it has to undergo the first-pass mechanism, but once the cannabis ultimately shows its action, they stay much longer than inhaling cannabis.  

Marijuana effects on liver

Doctors recommend marijuana for its medicinal advantages and therapeutic effects. Moreover, the chances are equal either it can benefit liver health or it can deteriorate the liver wellbeing. It all depends upon the consumption of marijuana. If not taken as advised by the doctors, if not inhaled or ingested for medicinal purposes and rather than it is consumed as a habit to get yourself high, euphoric, and intoxicated, then results are harmful as obvious.  

Marijuana; how it benefits the liver health

Medicinal cannabis, as doctors suggest, is helpful in many liver conditions like

• HIV
• Chronic hepatitis C
• Alcoholic or no alcoholic fatty liver disease
• Hepatic fibrosis
• Hepatic encephalopathy

  Now the question is how its benefits liver health in those particular conditions? The CB2 and CB1 receptors that are present in the liver are responsible for liver health. Activation of CB2 receptors and blocking of CB2 receptors is good for hepatic health as it alleviates fibrosis, decreases inflammation, and enhances hepatocyte survival.   And luckily cannabinoids like CBD activate the CB2 and block the CB1 receptors thus acting as a hepatic protective element that is quite useful if it is taken in underlying hepatic disease. So cannabidiol (CBD) having therapeutic effects helps the liver as

• It decreases hepatic inflammation
• Alleviate oxygen distress
• Decline in fibro genesis

  If marijuana is consumed alongside alcohol, then the therapeutic effect subsides.  

How marijuana harms hepatic health

Marijuana when is taken through the oral route issued by a Florida medical marijuana doctor or another mmj doctor in a location near you, it has to go through various steps before showing its medicinal, pharmacological, and also harmful side effects.   The inhaled cannabis shows instant results, as the instant recreational sensation, and euphoric state, soon these feelings wear off after some hours. That is not the case when cannabis is ingested. Although the onset of action is delayed when marijuana is taken orally. Once the effect is built, it is evident, prompt, and has a long onset of action. Meanwhile, it intoxicates the body with more power as compared to inhaled cannabis. That is why you need to be more careful while ingesting marijuana.   After passing through the first-pass metabolism that takes place in the liver, marijuana metabolites enter the bloodstream and brain. Once the THC and CBD enter in blood and brain, there is no U-turn, and the effect either beneficial or harmful will appear. Besides the therapeutic effects in many hepatic conditions, cannabis also worsens liver health.  

Chronic hepatitis C

Cannabis if taken for chronic hepatitis C, it increases the fatty liver. The doctor advised should be entertained with great care before taking cannabis. Those who have chronic hepatitis C need to practice extra care if they are addicted to cannabis. Although cannabis is antiviral, still its effects are not more beneficial and useful in those patients with chronic hepatitis.   It all depends upon the usage of cannabis with how much intensity you prefer to consume it. if it is ingested out of precautions, and if you went against your doctors prescribed amount, the cannabis effects are fatal and can lead to end-stage cirrhosis.   It is not a matter of liver when we talk about marijuana’s side effects. All psychoactive drugs have ultimately negative effects on mental health to the level that if you start taking these drugs you get addicted and when you want to get rid of that addiction, the withdrawal symptoms are even more fatal. The consumers who get addicted, have to experience the rehabilitation center to come back to a normal way of life.   These psychoactive agents or drugs directly act on the central nervous system and alter its regular way of pattern. Anxiety, cardiovascular effects, auditory or visual illusion, pseudo hallucination, ataxia, cognition, memory problems, and many more adverse effects have arisen on a high dose of marijuana.  

Final verdict

What exactly marijuana does to the human body, although the scientific study on it is not fully conducted yet, still it is obvious what it tends to do to our body and mind. What kind of risk factors and what therapeutic advantages it has?   It is fully understood that marijuana edibles do wonders when ingested. They bring relief from pain and create a joyful sensation in the body and mind. At the same time, they can damage mental health. Before taking it inside your body, ask your doctor how to take it to get benefit rather than harm.   Related: How To Get A Medical Marijuana Card in Florida

As marijuana grows in popularity, you can see a lot of edible made out cannabis these days. Cannabis is actually one of the substances we get from marijuana, which can also be used to manufacture medicines, rope, clothing, paper, and many other products. As a result, marijuana is not banned in many areas; thus, marijuana edible products can be easily seen in marijuana stores.
Medical marijuana edibles are foods, drinks, or other types of digestible ingredients infused with cannabis. Cannabis can be infused in different ways through several different processes. Most of our medically edible marijuana, including cookies, gums, and capsules that are infused using an oil extract processed. Other medically edible products are produced by extracting the drug from the flower with a direct solvent, such as butter.

Medical marijuana edibles contain tetrahydrocannabinol (THC), a psychoactive stimulant substance that can be smoked, warmed, or cooked for consumption. However, marijuana doctors say THC consumption is thought to produce a stronger feeling than smoking or inhaling.
The best part of edible is that they can produce a long time effect. Some can last up to eight hours! Even at lower doses, edible consumers can enjoy mild euphoria, relaxation, and a sense of acceptance of the situation for hours at a time. This is especially useful if you travel by car for a long time or wait a long time between activities.

 

How do medical marijuana edibles work?
Once upon a time, edibles were limited to homemade brownies that tasted pretty bad and contained a mysterious dose of THC. Today you can find medicinal cookies, popcorn, nut mixes, lollipops, ice cream, gummy bears, chocolate bars, chewing gum, etc.
Unlike inhaled cannabis, edible ones let the content of cannabinoids enter the bloodstream by digestion in the gastrointestinal tract. The process is much slower than inhalation but produces powerful effects. After consuming edible products, the experience can be very different from smoking or evaporating cannabis, so marijuana doctors advised patients to exercise caution to avoid taking excessive medication.

 

The Best Marijuana Edibles for Depression
Cannabis has been used as a medicine for centuries to treat depression. Today, studies show the antidepressant effect of cannabinoids in the hemp plant. In particular, the cannabinoid delta-9-tetrahydrocannabinol (THC) has been found to be useful, especially for depression.
Research also shows that consumers rely on cannabis edible products to help them with their lifestyle, wellness needs, and depression. Edibles can have a relaxing effect on the mind and body due to its cannabinoid composition. They are discreet and precisely formulated to promote system balance. Also, edibles are more than just a delicious delicacy; they are a popular way to relieve stress and depression.
The most significant advantage of cannabis edible is their low dose formulation. Many edible brands offer 3 mg – 5 mg – 10 mg strength, allowing you to practice titration to achieve the perfect effect. These small doses, low dose and also allow micro-dosing. The ability to create the optimal amount of cannabis “for testing” is one reason people are attracted to edible products for depression.

 

 

 

 

 

 

 

 

Below are some of the best marijuana edible strains to use for depression:
1. Soothing Cranberry Gummies – These edible gummies are one of the most delicious edible products available on the market to help depression. You can buy their blueberry and chill gummies in packs of 10 gummies with a concentration of THC: CBD in a ratio of 1: 1 (5 mg per dose). It would give you the same relaxing and calming effect.
2. Sympa-Tea – This cannabis infuses herbal tea is a good option for depression. 3mg of THC and 20mg of CBD in each bag work synergistically to create a calming effect that soothes muscle pain and stimulates the mind for better relaxation. You can keep the tea bag submerged longer for better taste. Its fast-acting effects and optimal cannabinoid composition make it an ideal choice for depression.
3. Indica Cinnamon Gummies – These delicious sweets and gummies will surely take you on an excellent night trip. Their cannabis-induced cinnamon candies are potent in THC derived from pure indica strains. Marijuana doctors say that these edibles are more effective and less aromatic to taste. You can find varieties of flavors of these edible products that will relax you before bed.

4. Sensi Chew Insomnia – The Sensi Chew Insomnia is a chocolate bar containing 100 mg of THC, divided into ten pieces. Each piece acts as a portion and would help you relax and fight depression. It contains 4 mg of melatonin to help you adjust to your sleeping habits. In combination with cannabis, melatonin enables you to stay asleep, has anti-inflammatory properties, and helps relieve pain and reduce stress levels. It is perfectly edible for depression.
5. Stratos THC Infuse Tabs – These edibles are an excellent alternative to prescription sleeping pills. They are the perfect solution for a good relaxation and were created to maximize the absorption of cannabinoids into our system. Infused with cannabis oil made from pure indica strains, these cards are intended for relaxation. Cannabis oil is used here and is prepared with CO2 oil extraction, and Indica strains are used in the extraction process to obtain THC, which creates a calming effect.
6. Kin Slips – Kin Slips offers a variety of sublingual products infused with cannabis. A pleasant mixture of Kin slips enters our body directly into our bloodstream through the mouth’s oral mucous membranes. Traditional marijuana edible, such as sweets or cakes infused with cannabis, when consumed, can take an hour or two to show their effects, while these edible strips are activated within 15 minutes of consumption.

 

7. Day Dreamers Dream Catcher – This smooth and creamy chocolate bar contains 360 mg of THC. The chocolate bar contains six pieces containing 60 mg of THC each, which makes serving easier. Each piece is equal to the amount of THC in marijuana, giving you a more consistent high.

 

Marijuana edible is an easy and forgiving way to consume marijuana and experience the health benefits. Most of these edible products are readily available, and you can buy them whenever you want, but you must use them according to what an All Natural MD Marijuana Doctor says.
Cannabis edible comes in different forms, varieties, and concentrations, and people react differently to doses, so it can be challenging to find the right amount. However, marijuana doctors suggest that beginners should start with about 4.25 milligrams of CBD if they have low levels of depression. Get Started today.

The gallbladder is a pouch-shaped, small organ located at the upper right side of the abdomen. Its function is to store bile which is secreted by the liver for metabolism of fatty foods. The organ is thus not essential and doctors typically opt for its removal when it causes health problems.

 

Cannabis, or marijuana, is an herb plant from the Cannabaceae family. It has been used for religious, medicinal, and other purposes for centuries. Cannabinoids are the active ingredients in marijuana and they are obtained from its leaves. THC (tetrahydrocannabinol) is the main cannabinoid in it; it is the key component that leads to a “high” and offers good pharmacological effects.

 

Marijuana edibles, also referred to as edibles, are famous for their strong and prolonged effects of THC. But marijuana doctors also suggest that they are not without their shortcomings.

 

Most edibles users are aware of the fact that they are costly; are hard to consume fully due to their powerful cannabis flavor; and often do not yield the high that consumers look forward to. Also, marijuana doctors say that edibles may produce inconsistent results and can sometimes cause health or digestive issues.

 

Edibles thus have a lot of pros and cons. The effects of marijuana edibles differ from one person to another, irrespective of whether a person has had gallbladder removal surgery or not. Most marijuana doctors suggest that the lack of a high (or other effects) is often not due to ‘no gallbladder’, but due to the quality of the edible consumed or the THC tolerance level of the user.

 

Marijuana edibles and Inconsistent results

If marijuana edibles are bought from the black market, then their effects are bound to erratic and the user’s experience may differ from one time to another.

 

Before the advent of laboratory testing for edibles, it was nearly impossible to find the correct dose during production and use. This meant that two different doses made from the same edible would have uneven percentages of compounds leading to really dissimilar results. The prediction of results is further compounded when the initial marijuana type and an edible’s infusion variety is not known.

 

Now that numerous states in the US have legalized marijuana, laboratory testing during different production stages of edibles is required by the states. This has meant that it is much simpler to identify the full dose of an edible, including the portion of each edible dose, resulting in the production of edibles with really predictable and consistent effects.

 

Marijuana doctors say that edible manufacturing firms have made it mandatory for utilization of standardized and reliable starting components which has gone a long way towards ensuring stable marijuana edible experiences time and again. The firms have formed business contracts with suppliers of marijuana leading to regular supply of great quality cannabis that is used in their edibles.

 

Related Article: More Information on Marijuana Edibles

 

There are several legal marijuana companies that have begun opting for infusions of specific strains to ensure that the end edible product has another layer of uniformity. Marijuana doctors suggest that this will ensure that consumers will be able to reliably predict the effects of that edible as well as deduce their sensitivity to that specific branded strain infusion.

 

Marijuana doctors say that consumers also need have knowledge about the ‘Entourage Effect’ before selecting a particular edible. The ‘Entourage Effect’ refers to the unique interactions of all the compounds present in cannabis plants so as to create varied and distinctive outcomes when eaten as a whole, as opposed to the effect realized during consumption of singular cannabis compounds like CBD or THC in the same quantity. According to marijuana doctors, some compounds in cannabis include flavonoids, terpenes, and cannabinoids, etc.

 

Now, edible manufacturing companies have begun studies on the significance of ‘Entourage Effect’ on varied marijuana consumption experiences. Accordingly, keeping in mind the compound interactions, the firms have adapted the results of such studies to make relevant changes in the edibles formulations for better consumer experiences.

 

Manufacturers of marijuana edibles ensure that the natural percentages of CBD, THC, terpenes, THCV, CBG, and other compounds in the matrix are maintained. Thus, they are able to preserve the identical effects released by specific cannabis types in their varied merchandise and across consignments.

 

Marijuana doctors say that some companies also insert extra terpenes in the edibles to regulate the distinctiveness of the effects that consumers experience. For example, the addition of Pinene offers a boost and higher energy levels, while Myrcene insertion offers a nuanced calming sensation.

 

It may be noted that the effects of terpenes differ from one user to another. However, the experiences are more or less the same for most users. Hence, consumers need to take extra care to understand the types of terpenes and their ratios in edibles so as to be able to enjoy consistent and predictable experiences whenever they consume it.

 

Why do some consumers not get high after consuming marijuana edibles?

It is a known fact that the psychoactive impact of edibles is more potent than smoking marijuana. However, some consumers do not get high after consuming edibles. Currently, the exact cause is not known and scientists are still conducting studies to comprehend this occurrence. Marijuana doctors suggest that there may be some possible explanations for such a phenomenon.

 

It is important to know that the effective dosage range of marijuana is really variable. This indicates that THC effects may become evident in some consumers after dosage of just 2.4 mg THC, while it may be 24 mg for some, while for some others it may go as high as 245 mg of THC dose. Still, there are some consumers who do not feel the effects at all, whatever the dose.

 

Due to the above fact, ascertaining a base dose for production of some cannabis effects, such as a feeling of being high, is quite difficult. It is possible that some customers may have a really high tolerance level for THC and as they never did consume a dose large enough to get high, they incorrectly assume that marijuana edibles have no effect on them.

 

Marijuana doctors say that the First Pass Metabolism mechanism also needs to be considered whilst trying to understand why some people don’t get high on edibles. First Pass Metabolism refers to the method of filtration of unfamiliar compounds in blood by the liver before the circulation of blood across other areas of the body. Some people may have a stronger than normal first pass effect, while it may be weaker in others.

 

It may be noted that after ingestion of marijuana edibles a big chuck of active THC is dumped by the liver before the blood can travel to the brain and cause the feeling of being high. The level of THC that is dumped and which get passed onto the bloodstream and the brain is dependent on the first pass metabolism mechanism. In most cases, the level of active THC that circulates out of the liver is often potent enough to present observable psychoactive outcomes.

 

Marijuana doctors suggest that consumers who are unable to get high after consuming marijuana edibles may opt for sublingual absorption of THC, and verify if that makes a difference. It means that the edible should not be swallowed or chewed, but allowed to melt in the mouth like a lozenge. The cannabinoids will then enter the bloodstream and reach the brain directly via the oral glands and mucus membranes, thus circumventing the metabolism processes of the liver. Get Started on your medical marijuana card at one of our offices in Lakeland, Sarasota or Orlando today.