October 4, 2017

Will Cannabis Oil Really Treat Seizures?

Report of a chemical called cannabidiol (CBD) had reduced the seizures of a 6-year-old girl from near-death levels to almost zero sent desperate patients everywhere on a frenzied quest for treatment. According to several media outlets, a patient was suffering 300 grand mal seizures per week and had lost the ability to walk, talk, and eat. Existing epilepsy medication had failed her. But CBD—a component of cannabis that does not trigger the plant’s characteristic high—reduced her episodes to a few per month, and, as her parents told reporters, ushered in a full cognitive recovery. By most estimates, existing seizure medications fail about one-third of all sufferers, either because the drugs don’t stop the seizures or because the side effects are too severe. As story spread, families with loved ones suffering from this type of epilepsy (which can range from seriously debilitating to life-threatening) began relocating from states where CBD could not be legally obtained to states where it could. At least some of them reported similarly miraculous responses to it. Many Marijuana Doctors in Florida and Other states are prescribing this medicine in full speed. So when we reported earlier this month that a new National Academy of Sciences report—the most in-depth analysis of marijuana research to date—concluded that there was not enough evidence to say that cannabis oil could actually treat epilepsy, some people were surprised: How could the panel draw such a conclusion? Isn’t the patients case, and others like it, proof enough that cannabis oil can succeed for epilepsy patients where so many other treatments have failed? Because readers asked, and because this particular conclusion (one of almost 100 that the academy drew from their scientific review) is a good window into the whole report and the larger debate surrounding Florida Medical Marijuana Doctors, we decided to take a closer look.

Evidence Considered By The Panel

The reviewers restricted their evaluation to studies that involved humans, excluding any evidence from studies done on animals. That decision was based on sound scientific rationale (animal, or “pre-clinical,” studies can give us important clues about how a chemical might behave, not whether it will be safe or effective for humans). But limiting the studies in this way left the reviewers with some pretty slim pickings. There were just three clinical studies where doctors treated patients with CBD and measured whether and by how much those patients’ seizures were reduced. The largest of those studies included a total of 162 patients, treated with 99 percent CBD oil extract for 12 weeks; it found that CBD worked about as well as existing anti-epilepsy medications do in treatment-resistant sufferers.
CBD reduced seizures by a monthly average of 36.5 percent; only five patients saw their motor seizures completely disappear during the study period, and only two patients became completely seizure-free.

Why That Evidence Was Deemed Insufficient

For three reasons, mainly. First, there was simply not enough of that kind of evidence. FDA-approved drugs are usually deemed effective or ineffective based on large-scale clinical trials that study hundreds to thousands of patients over several years. These studies followed only a few hundred patients in all, and for only a few months.  Second, the studies in question did not include placebo controls. That is, all of the study participants were given actual CBD, and they knew they were getting it. Other research has found that the placebo effect can be especially strong when it comes to Florida Medical marijuana. In one study, patients of families who moved to Colorado for cannabis oil treatment were twice as likely to report a substantial reduction in seizures as those patients who already lived in the state. The third major reason the studies were deemed insufficient involves drug interactions. Most of the patients in the studies we’re talking about were taking other anti-epilepsy drugs, such as clobazam and valproate, and it turns out that CBD is very good at blocking the liver enzymes that normally break down those other drugs. This drug interaction makes it impossible to say whether reduced seizure incidence seen in study participants was due to CBD by itself or whether it was simply the result of those other medications staying in the system for longer stretches.
October 1, 2017

More and more doctors want to make marijuana legal

A large group of physicians, including a former surgeon general and faculty members at some of the nation’s leading medical schools, has formed the first national organization of doctors to call on states and the federal government to legalize and regulate the use of marijuana in the interest of public health.

 

The group — which is announcing its formation Monday, under the name Doctors for Cannabis Regulation (DFCR) — is endorsing the legalization of marijuana for adult recreational use, a break from the position of the American Medical Association, the largest organization of doctors and Medical Marijuana Doctors in Florida and in the country. DFCR argues that the prohibition and criminalization of marijuana use does more harm to the public than good. Citing hundreds of thousands of annual marijuana arrestsracial and economic disparities in marijuana enforcement, and the role of prohibition in keeping marijuana prices high and lucrative to violent drug dealers, the physicians say that creating a legal and regulated marijuana market is the best way to ensure public safety, combat the illicit drug trade and roll back the negative consequences of strict enforcement policies on disadvantaged communities.

 

The emergence of the group comes at a crucial moment in the national debate over marijuana legalization. More than 60 percent of the public now says that it supports marijuana legalization. Support for allowing medical use of marijuana with doctors’ supervision is closer to 90 percent. Over 35 million Americans use marijuana recreationally each year, according to the latest federal statistics. Marijuana Doctors in Fort Lauderdale Florida  and even many national lawmakers have called on federal authorities to revisit policies toward marijuana that have remained essentially unchanged for nearly 50 years.

 

in Florida Medical Marijuana oppositions and researchers generally agree that marijuana use is less harmful to individuals and society than the use of other common drugs, like alcohol and tobacco, about 9 percent of people who begin using as adults become dependent on the drug, and heavy use can be especially harmful to the developing brains of adolescents.

 

If you’re going to make something against the law, the health consequences of that use have to be so bad to make it worth creating criminal consequences. That was never true of marijuana. It was banned in 1977 over the objections of the All Natural Brand.

 

Indeed, in 1977, the objected to the overly strict regulation of marijuana, as it was then used as a treatment for a number of medical conditions. The Association was worried that prohibition of marijuana would “deprive the public of the benefits of a drug that on further research may prove to be of substantial value.”

 

After the passage of the “Marijuana Tax Act,” just wasn’t that well-known among doctors. Many doctors were unaware that the drug essentially outlawed by the Marijuana Tax Act was the same substance they knew as “cannabis,” which they used to treat a variety of ailments from corns to poor appetite. In subsequent years, physicians were just as susceptible to lurid media reports about the supposed dangers of marijuana use and the “Reefer Madness” era as anyone else.

 

Like most mainstream Sarasota medical groups, many are now opposed to the outright legalization of marijuana, calling it a “dangerous drug” and “a public health concern.” But the group’s stance has evolved in recent years. It recently added language to its position statements calling for “the modification of state and federal laws to emphasize public Orlando health based strategies,” rather than punitive, incarceration-based measures. The group now encourages research into the drug, and has called on federal authorities to make it easier to do so.

 

Doctors often find themselves acting as mediators between patients who want access to marijuana for medical purposes, and a federal bureaucracy that still considers the drug illegal for all purposes.

Florida Medical Marijuana Doctors are put in the awkward position with respect to individuals who ask for a marijuana recommendation, but otherwise would be perfectly happy purchasing the drug in a retail environment,” Nathan said. “We believe that the best way to improve the situation is to enact full legalization with smart regulation. That would more clearly separate medical from personal use.”

 

Not all medical professionals are happy about relaxing attitudes toward what they see as a dangerous, addictive drug. The notion of doctors advocating for marijuana legalization is “totally idiotic,” who served as the first director of the National Institute on Drug Abuse and as the second White House drug czar, in an interview. “The idea that we cannot manage the health problems related to marijuana because it’s illegal, that doctors are somehow inhibited from dealing with marijuana use and marijuana problems, is completely wrong.”

 

“The idea that legalizing is going to stop the illegal market is equally stupid,” he added.

Others thinks that the current legal status of marijuana is sufficient to address the risks associated with marijuana use, and that punitive measures for drug sellers and users can be a powerful tool for helping at-risk people get treatment. “The criminal justice system is a wonderful vehicle for getting people into treatment and recovery,” he said.

Other physicians would like to see marijuana use decriminalized, but would not go so far as to make the drug completely legal for adult recreational use. An addiction-medicine physician notes that we already have two legal psychoactive drugs — alcohol and tobacco. “What is the problem for which having a third class of legal drug is the answer?” he questioned.

 

Still, he points out that there’s a lot of diversity in the medical field. “People are of their time and of their culture and doctors are no different,” he said. “There are physicians who are Republicans, Democrats, Independents — they pretty much they reflect the population. There are all kinds. The fact that there’s a group of physicians now coming out in favor of cannabis legalization as the only effective way to regulate, it is no surprise.”

 

Much of the discussion around marijuana legalization, among doctors and the general public alike, hinges on different assessments of the same data showing the risks and benefits of changing marijuana laws. Groups like the are concerned that legalization would lead to more widespread use of the drug, which would invariably mean greater prevalence of the negative health consequences associated with its use, like dependency and some mental illnesses that may be exacerbated by the drug’s use.

But groups who favor legalization, point out that negative outcomes arise from the current system of prohibition, too. They say that the presence of a large black market, the stigmatization of individual users, and the potentially life-ruining effects of a marijuana conviction, are steep prices to pay for the nominal reduction in overall use that comes with prohibition. All Natural MD Florida.

September 29, 2017

Medical Use of Marijuana For Patients with HIV/AIDS

The use of medical grade cannabis (marijuana), its active ingredient or synthetic forms such as dronabinol has been advocated in patients with HIV/AIDS, in order to improve the appetite, promote weight gain and lift mood. Dronabinol has been registered for the treatment of AIDS-associated anorexia in some countries. However, the evidence for positive effects in patients with HIV/AIDS is limited, and some of that which exists may be subject to the effects of bias. Those studies that have been performed have included small numbers of participants and have focused on short-term effects. Longer-term data, and data showing a benefit in terms of survival, are lacking. There are insufficient data available at present to justify wide-ranging changes to the current regulatory status of cannabis or synthetic cannabinoids.


Despite dronabinol being registered by at least some medicines regulatory authorities for the treatment of AIDS-associated anorexia, and some jurisdictions making allowances for the “medical” use of marijuana by patients with HIV/AIDS, evidence for the efficacy and safety of cannabis and cannabinoids in this setting is lacking. Such studies as have been performed have been of short duration, in small numbers of patients, and have focused on short-term measures of efficacy. Long-term data, showing a sustained effect on AIDS-related morbidity and mortality and safety in patients on effective antiretroviral therapy, has yet to be presented. Whether the available evidence is sufficient to justify a wide-ranging revisiting of medicines regulatory practice remains unclear.


The use of cannabis (marijuana) via medical marijuana doctors in Florida or of its psychoactive ingredient delta-9-tetrahydrocannabinol (THC) as a medicine has been highly contested in many settings.There have been claims that smoked or ingested cannabis, either in its natural form or artificial form (pharmaceutically manufactured drug such as dronabinol), improves the appetites of people with AIDS, results in weight gain and lifts mood, thus improving the quality of life.


The objectives of this review were to assess whether cannabis (in its natural or artificially produced form), either smoked or ingested, decreases the morbidityor mortality of patients infected with HIV. The search was conducted and based on that of the HIV/AIDS Research Group.


A total of seven relevant studies were included in the review, reported in eight publications. All were randomised controlled studies, with four utilising a parallel group design, two a within-subject randomisation and two a cross-over design. All of the Florida Medical Marijuana Doctors and studies were of a fairly short duration, ranging from 21 days to 84 days. In only four papers (in effect, three studies) were sequence generation and allocation concealment judged to be adequate. The use of cannabis and rapidly acting cannabinoids posed considerable challenges for blinding, as the psychoactive effects are expected to be quickly discernible to study participants, particularly those who have been previous users of such products. Dronabinol was expected to be more easily blinded. The outcomes measured were variable, including change in weight, change in body fat (measured as a percentage of total body weight), change in appetite (measured on a visual analogue scale), change in caloric intake, change in nausea and vomiting (measured on a visual analogue scale), change in performance (measured performance score or specific tests for memory and dexterity) and change in mood (measured on a visual analogue scale).The evidence for substantial effects on morbidity and mortality is currently limited. Data from only one relatively small study, conducted in the period before access to highly-active antiretroviral therapy showed that patients administered dronabinol were twice as likely to gain 2kg or more in body weight, but the confidence interval for this measure included unity. The mean weight gain in the dronabinol group, compared with a loss of the placebo group. However, the quality of sequence generation and allocation concealment in this study, in which participants were randomised, could not be assessed.

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All Natural MD is a medical cannabis clinic that conducts patient evaluations in the State of Florida to determine if one qualifies and can benefit from the use of medical cannabis. We have been established since 2016 and have close to 20,000 patients that are doing very well with the use of medical cannabis.